Correlates of CD4+ and CD8+ lymphocyte counts in high-risk immunodeficiency virus (HIV)-seronegative women enrolled in the Women's Interagency HIV Study (WIHS)

Summary:

Measurements of CD4 and CD8 cells are commonly used to monitor a variety of immunodeficiency disorders including HIV. Studies of HIV infection often compare values from HIV-uninfected controls, including CD4 and CD8 lymphocyte counts. Nonetheless, little is known regarding factors associated with CD4 and CD8 cell numbers in HIV-uninfected individuals. To ascertain potential factors associated with differences in CD4 and CD8 cells among HIV negative women, we studied these cells in a group of 953 women, enrolled as HIV-negative comparators in the Women’s Interagency HIV Study. To our knowledge, this study represents the largest such investigation yet conducted.

Citation: 

Nowicki M, Karim R, Mack W, Minkoff H, Anastos K, Cohen M, Greenblatt R, Young M, Gange S and Levine A. Correlates of CD4+ and CD8+ lymphocyte counts in HIV- women: WIHS. Hum Immunol 2007;68(5):342-349.