Correlates of CD4+ and CD8+ lymphocyte counts in high-risk immunodeficiency virus (HIV)-seronegative women enrolled in the Women's Interagency HIV Study (WIHS)


Measurements of CD4 and CD8 cells are commonly used to monitor a variety of immunodeficiency disorders including HIV. Studies of HIV infection often compare values from HIV-uninfected controls, including CD4 and CD8 lymphocyte counts. Nonetheless, little is known regarding factors associated with CD4 and CD8 cell numbers in HIV-uninfected individuals. To ascertain potential factors associated with differences in CD4 and CD8 cells among HIV negative women, we studied these cells in a group of 953 women, enrolled as HIV-negative comparators in the Women’s Interagency HIV Study. To our knowledge, this study represents the largest such investigation yet conducted.


Nowicki M, Karim R, Mack W, Minkoff H, Anastos K, Cohen M, Greenblatt R, Young M, Gange S and Levine A. Correlates of CD4+ and CD8+ lymphocyte counts in HIV- women: WIHS. Hum Immunol 2007;68(5):342-349.